LET THE SPECULATION BEGIN!
I'm thinking 3rd quarter 2011 release date for the first beta, and it'll have full hardware acceleration, as well as mark the discontinuation of IE6/IE7 (finally). Firefox 4 will be released already, and will not only contain JIT compilation (through use of the Taramin project), but will continue Mozilla's efforts to reduce memory consumption. Safari will continue trudging along, Opera will make a huge comeback in the browsing industry, and of course Google will continue its march toward global domination with Chrome.
Yep, that about sums it up.